| Government Ayurveda College, Vadodara, Gujarat |
Vadodara |
Gujarat |
M.D |
2019 |
An Analytical study of Lyophilized Haridra and Its comparitive Stability studies with standered ( Simple Haridra Powder) |
Ram K Bhuva |
Dr Atanu Anil Bairagi HoD, Reader, Government Ayurveda college, vadodara, Gujarat |
Dr Vaishali N Patel Joint Commissioner( Testing) Food & Drug's Laboratory, Vadodara |
The study was aimed at An Analytical Study of Lyophilized Haridra and Its Comparative Stability Studies with a Standard (Simple) Haridra Powder.
v In Simple Haridra powder and Lyophilized Haridra powder both are same in Pharmacognostical characteristics. v Simple Haridra powder is prepared by Ayurveda classical method whereas Lyophilized Haridra powder is prepared by mechanised method by the use of freeze drying machine. v Simple Haridra powder is found more in quantity than Lyophilized Haridra powder i.e. from 3 kg raw Haridra rhizome 1.015 kg simple Haridra powder can be obtain whereas 9.6 kg raw Haridra rhizome 1.175 kg Lyophilized powder can be obtained. That means Lyophilized Haridra powder has less finished quantity than simple Haridra powder. From this we can conclude that Lyophilized Haridra powder is much more potent than simple Haridra powder. v Lyophilized Haridra powder active ingredient such as curcumin 1.660 % (w/w) in initial month and 1.651% (w/w) in twelve month was found whereas in simple Haridra powder active ingredient such as Curcumin 0.910 % (w/w) in initial month and 0.903 % (w/w) in twelve month was found. That means Lyophilized Haridra powder is much more potent so that by taking in less quantity it shows maximum efficacy. v According to IP permissible limit of Curcumin is not less than 1.5% (w/w) whereas in simple Haridra powder it is 0.910 % (w/w) so according to IP it is not able to fulfil the criteria for preparation of medicine. v Analytical parameter such as Water soluble extractive and Alcohol soluble extractive are found more in Lyophilized Haridra powder than simple Haridra powder so Lyophilized Haridra powder has more efficacy than Simple Haridra powder. v Loss on drying is found more in Simple Haridra powder compared to Lyophilized Haridra powder which indicate that Simple Haridra powder contain more moisture content than Lyophilized Haridra powder moreover Microbial limit test’s Summary and Conclusion An analytical study of Lyophilized Haridra and its comparative stability studies with a standard (simple) Haridra powder. 153 parameter such as Total plate count, Total yeast and mould count is more in simple Haridra powder than Lyophilized Haridra powder but in permissible limit of API. So simple Haridra powder has less shelf-life than Lyophilized Haridra powder. v Preparation of Simple powder from drying to powder form is too long, requires lots of days and includes more labour work whereas Lyophilized powder is prepared in machine so it consume less time. v In our country Freeze drying machine are more costly so preparation of Lyophilized powder is expensive than simple powder. v Lyophilized Haridra powder is 4-5 times more costly than simple Haridra powder. v Analytical parameters such as Loss on drying, Water soluble extractive, Alcohol soluble extractive, Total ash, Acid insoluble ash, Assay of curcumin by HPLC, microbial limit test are more in Lyophilized Haridra powder than simple Haridra powder. So by these parameters Lyophilized Haridra powder is more stable than simple Haridra powder. v So at the and by looking at the Analytical parameters we can conclude that by Lyophilized Haridra powder more stable than simple Haridra powder. |
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